Description

2-Pyrrolidinone, 1-Methyl-3-(2,2,2-Trifluoro-1-Hydroxyethylidene)- (9Ci) is a high-value, specialized heterocyclic building block featuring a trifluoromethylated hydroxyethylidene moiety. This compound matters for its unique structural properties, which make it a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals. Research and development teams in fine chemical and life science industries need this material for creating novel active ingredients, particularly where the introduction of fluorine atoms is desired to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity.
• Fluorinated Building Block: Serves as a versatile precursor for introducing the CF3-substituted pyrrolidinone scaffold into more complex molecular architectures.
• Material Science Research: Investigated for potential use in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-Pyrrolidinone, 1-Methyl-3-(2,2,2-Trifluoro-1-Hydroxyethylidene)- (9Ci)
CAS No.	204448-78-2
Molecular Formula	C7H8F3NO2
Molecular Weight	195.14 g/mol
Synonyms	1-Methyl-3-(2,2,2-trifluoro-1-hydroxyethylidene)pyrrolidin-2-one; 1-Methyl-3-(trifluoroacetyl)methylenepyrrolidin-2-one; 3-(2,2,2-Trifluoro-1-hydroxyethylidene)-1-methyl-2-pyrrolidinone; N-Methyl-3-(trifluoroacetyl)methylene-2-pyrrolidinone; 204448-78-2; 1-Methyl-3-(2,2,2-trifluoro-1-hydroxyethylidene)-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinone, 1-Methyl-3-(2,2,2-Trifluoro-1-Hydroxyethylidene)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.