Description

Propargyl-Peg3-Bromide is a high-purity, functionalized polyethylene glycol (PEG) linker featuring a terminal propargyl group and a bromide handle. This bifunctional reagent is essential for click chemistry and bioconjugation strategies, enabling the precise and efficient construction of complex molecular architectures. It is a critical building block for researchers and manufacturers in pharmaceutical development, materials science, and advanced diagnostics.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of Antibody-Drug Conjugates (ADCs) and other targeted therapeutics.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for labeling, surface modification, and polymer synthesis.
• Bioconjugation: Facilitates the site-specific attachment of drugs, dyes, or other functional molecules to proteins, peptides, and oligonucleotides.
• Polymer Chemistry: Serves as a functional initiator or monomer for creating PEG-based block copolymers with tailored properties.
• Materials Science: Used to modify surfaces and nanoparticles to introduce bio-orthogonal reactivity for sensing and diagnostic applications.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) and other chemical proteomics techniques.

Basic Information

Product Name	Propargyl-Peg3-Bromide
CAS No.	203740-63-0
Molecular Formula	C12H21BrO3
Molecular Weight	293.20 g/mol
Synonyms	1-Bromo-3,6,9-trioxa-11-dodecyne; 2,5,8,11-Tetraoxatridec-12-yn-13-yl Bromide; Propargyl-PEG3-Br; 3-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)prop-1-yne; Bromo-PEG3-propargyl; Propargyl-PEG3-alkyl bromide; Propargyloxy-PEG3-bromide; 11-Bromo-3,6,9-trioxaundec-1-yne
EINECS	Contact for details

Quality Control

Every batch of Propargyl-Peg3-Bromide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and other relevant analytical methods. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.