Description

(E)-4-(5-Bromo-2-Fluorophenyl)But-3-En-2-One CAS NO 203194-33-6 is a high-purity, synthetic organic compound featuring a bromo-fluorophenyl substituted α,β-unsaturated ketone (enone) structure. This molecule serves as a versatile and critical pharmaceutical intermediate and building block in advanced organic synthesis. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic system.
• Material Science Research: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) or semiconductors, due to its conjugated system.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create biaryl structures.
• Michael Addition Substrate: The α,β-unsaturated carbonyl moiety acts as an acceptor in Michael addition reactions for carbon-carbon bond formation.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	(E)-4-(5-Bromo-2-Fluorophenyl)But-3-En-2-One
CAS No.	203194-33-6
Molecular Formula	C10H8BrFO
Molecular Weight	243.07 g/mol
Synonyms	(E)-4-(5-Bromo-2-fluorophenyl)but-3-en-2-one; 4-(5-Bromo-2-fluorophenyl)-3-buten-2-one; 1-(5-Bromo-2-fluorophenyl)-3-buten-2-one; (E)-1-(5-Bromo-2-fluorophenyl)but-1-en-3-one; 3-Buten-2-one, 4-(5-bromo-2-fluorophenyl)-, (E)-; 5-Bromo-2-fluorochalcone (common name); 4-(5-Bromo-2-fluorophenyl)-3-buten-2-one (E)-
EINECS	Contact for details

Quality Control

Our (E)-4-(5-Bromo-2-Fluorophenyl)But-3-En-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be moisture-sensitive. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.