Description

1-Chloro-4-Fluoro-2-Iodobenzene is a high-purity halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its unique combination of chlorine, fluorine, and iodine substituents makes it a versatile intermediate for introducing multiple halogen functionalities into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where specific halogen patterns are required for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings, leveraging the reactive iodine site.
• Fluorine Chemistry: The presence of both fluorine and iodine allows for further selective functionalization, useful in medicinal chemistry for modulating pharmacokinetics.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	1-Chloro-4-Fluoro-2-Iodobenzene
CAS No.	202982-68-1
Molecular Formula	C6H3ClFI
Molecular Weight	256.44 g/mol
Synonyms	2-Iodo-1-chloro-4-fluorobenzene; 4-Fluoro-2-iodo-1-chlorobenzene; 1-Chloro-4-fluoro-2-iodobenzene; 2-Chloro-5-fluoroiodobenzene; Benzene, 1-chloro-4-fluoro-2-iodo-; 202982-68-1; 4-Fluoro-1-chloro-2-iodobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Fluoro-2-Iodobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.