Description

2-(Benzyloxy)-1-Bromo-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents on a benzyloxy-protected benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display technologies.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to form biaryl structures.
• Protecting Group Chemistry: The benzyloxy group can be used as a protecting group for phenols in multi-step synthetic sequences.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-(Benzyloxy)-1-Bromo-4-Fluorobenzene
CAS No.	202857-88-3
Molecular Formula	C₁₃H₁₀BrFO
Molecular Weight	281.12 g/mol
Synonyms	1-Bromo-2-(benzyloxy)-4-fluorobenzene; 4-Fluoro-2-(benzyloxy)bromobenzene; 2-Benzyloxy-1-bromo-4-fluorobenzene; 1-Bromo-4-fluoro-2-(phenylmethoxy)benzene; Benzene, 1-bromo-2-(benzyloxy)-4-fluoro-; (2-Benzyloxy-5-fluorophenyl)bromide; 4-Fluoro-2-(phenylmethoxy)-1-bromobenzene; 2-Bromo-5-fluorophenyl benzyl ether
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-1-Bromo-4-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.