Description

3'-Fluoro-5'-(Trifluoromethyl)Acetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique trifluoromethyl and fluorine substituents make it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active ingredients, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other fluorinated polymers with specialized optical and electronic properties.
• Chemical Biology Probes: Employed in the creation of fluorinated probes and tags for studying protein-ligand interactions and metabolic pathways.
• Cross-Coupling Reactions: A valuable substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated motifs.

Basic Information

Product Name	3'-Fluoro-5'-(Trifluoromethyl)Acetophenone
CAS No.	202664-54-8
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-[3-Fluoro-5-(trifluoromethyl)phenyl]ethanone; 3-Fluoro-5-(trifluoromethyl)acetophenone; 3'-Fluoro-α,α,α-trifluoro-5'-methylacetophenone; 3-Fluoro-5-trifluoromethylacetophenone; 3-Fluoro-5-(trifluoromethyl)phenyl methyl ketone; 1-(3-Fluoro-5-(trifluoromethyl)phenyl)ethan-1-one; 3'-Fluoro-5'-trifluoromethyl acetophenone
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-5'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.