Description

2'-Fluoro-5'-(Trifluoromethyl)Acetophenone is a high-value fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by pharmaceutical R&D and agrochemical innovators for the development of novel active ingredients, as well as by specialty chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Advanced Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and optical properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial laboratories studying the effects of fluorination on molecular properties and reactivity.

Basic Information

Product Name	2'-Fluoro-5'-(Trifluoromethyl)Acetophenone
CAS No.	202664-53-7
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(2-Fluoro-5-(trifluoromethyl)phenyl)ethan-1-one; 2-Fluoro-α,α,α-trifluoro-5-acetylbenzene; 2-Fluoro-5-(trifluoromethyl)acetophenone; 2'-Fluoro-α,α,α-trifluoro-5'-methylacetophenone; 1-Acetyl-2-fluoro-5-(trifluoromethyl)benzene; 2-Fluoro-5-trifluoromethylacetophenone; 2-Fluoro-α,α,α-trifluoro-p-acetophenone
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-5'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.