Description

Ethanone, 2,2,2-Trifluoro-1-[2-(Methylamino)Phenyl]- (9Ci) CAS NO 202270-41-5 is a specialized trifluoromethyl ketone derivative featuring an ortho-methylamino phenyl substituent, making it a valuable fluorinated building block. This compound is significant for its role in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate this unique trifluoromethylated motif into novel molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs) due to its specific steric and electronic profile.
• Fluorinated Material Research: Acts as a monomer or modifier in the development of specialty polymers, coatings, and liquid crystals with improved chemical resistance and optical properties.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies to explore enzyme inhibition and receptor binding.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-[2-(Methylamino)Phenyl]- (9Ci)
CAS No.	202270-41-5
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	2,2,2-Trifluoro-1-[2-(methylamino)phenyl]ethanone; 1-[2-(Methylamino)phenyl]-2,2,2-trifluoroethanone; 2-(Methylamino)phenyl trifluoromethyl ketone; 2,2,2-Trifluoro-1-(2-methylaminophenyl)ethanone; 2-Methylaminophenyl trifluoromethyl ketone; N-Methyl-2-amino-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-2'-(methylamino)acetophenone; 202270-41-5
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-[2-(Methylamino)Phenyl]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.