Description

2'-Fluoro-5'-(Trifluoromethyl)Acetophenone is a high-purity fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and fluoro substituents impart desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that benefit from enhanced efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating fluorinated polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the research and manufacture of specialized ligands for catalysis and molecular recognition.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and new fluorination methodologies in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific fluorinated target molecules.

Basic Information

Product Name	2'-Fluoro-5'-(Trifluoromethyl)Acetophenone
CAS No.	202264-53-7
Molecular Formula	C9H4F4O
Molecular Weight	204.12 g/mol
Synonyms	1-(2-Fluoro-5-(trifluoromethyl)phenyl)ethan-1-one; 2-Fluoro-α,α,α-trifluoro-5-acetylbenzene; 2-Fluoro-5-(trifluoromethyl)acetophenone; 2'-Fluoro-α,α,α-trifluoro-5'-methylacetophenone; 1-Acetyl-2-fluoro-5-(trifluoromethyl)benzene; 2-Fluoro-5-trifluoromethylacetophenone; 2-Fluoro-5-(trifluoromethyl)phenyl methyl ketone
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-5'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.