Description

(S)-5,5,5,5',5',5'-Hexafluoroleucine Hydrochloride is a high-purity, non-natural amino acid derivative characterized by its incorporation of six fluorine atoms, which significantly alters its physicochemical and metabolic properties. This compound is a critical chiral building block for the synthesis of novel peptides and peptidomimetics, offering enhanced stability, lipophilicity, and bioavailability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing advanced therapeutics, including protease inhibitors, metabolic modulators, and targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptidomimetic Design: Used to incorporate fluorinated leucine analogs into peptide backbones to enhance metabolic stability, membrane permeability, and binding affinity.
• Protease Inhibitor Synthesis: Serves as a crucial component in the structure-based design of inhibitors for various proteases, leveraging the steric and electronic effects of the hexafluoroleucine side chain.
• Biochemical Research: Employed as a tool compound in studies investigating protein folding, stability, and protein-protein interactions using fluorine-labeled amino acids.
• Positron Emission Tomography (PET) Tracer Development: Potential precursor for the synthesis of fluorine-18 labeled compounds for diagnostic imaging applications.
• Agrochemical Research: Investigated for the development of novel peptides with pesticidal or plant growth regulation activity.

Basic Information

Product Name	(S)-5,5,5,5',5',5'-Hexafluoroleucine Hydrochloride
CAS No.	201930-89-4
Molecular Formula	C6H8F6NO2 • HCl
Molecular Weight	275.59 g/mol (Free base: 240.13)
Synonyms	(S)-5,5,5,5',5',5'-Hexafluoroleucine HCl; (2S)-2-Amino-5,5,5,5',5',5'-hexafluoro-4-methylpentanoic acid hydrochloride; F6-Leu-OH • HCl; Hexafluoroleucine hydrochloride; (S)-Hexafluoroleucine HCl; 5,5,5,5',5',5'-Hexafluoro-L-leucine hydrochloride; L-Hexafluoroleucine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-5,5,5,5',5',5'-Hexafluoroleucine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 98% (HPLC). Each lot is fully characterized by NMR (1H, 19F, 13C), mass spectrometry, chiral HPLC, and elemental analysis to confirm identity, enantiomeric purity, and chemical composition. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.