Description

(3S)-3-Fmoc-Amino-1-Diazo-2-Butanone CAS NO 201864-70-2 is a specialized, high-purity building block used in advanced organic synthesis. This compound is valued for its role as a protected amino diazoketone, enabling precise and efficient peptide coupling and macrocyclization reactions under mild conditions. It is an essential reagent for pharmaceutical researchers and process chemists developing novel peptide-based therapeutics, proteolysis-targeting chimeras (PROTACs), and other complex bioactive molecules.

Application

• Peptide Synthesis: A key intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• PROTACs Development: Used in the construction of linker-warhead conjugates for targeted protein degradation platforms.
• Macrocyclization: Facilitates ring-closing metathesis and other cyclization strategies to create constrained peptide architectures.
• Bioconjugation: Serves as a reactive handle for site-specific labeling and functionalization of biomolecules.
• Medicinal Chemistry Research: Employed in the discovery and optimization of new chemical entities, particularly in oncology and metabolic disease research.
• Process Chemistry: Used in the scalable production of active pharmaceutical ingredients (APIs) requiring diazoketone intermediates.

Basic Information

Product Name	(3S)-3-Fmoc-Amino-1-Diazo-2-Butanone
CAS No.	201864-70-2
Molecular Formula	C19H17N3O3
Molecular Weight	335.36 g/mol
Synonyms	Fmoc-Dap(N3)-OH; (3S)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-1-diazo-2-butanone; Fmoc-L-2,3-diaminopropionic acid diazoketone; Fmoc-Dap(Diazoketone)-OH; Nα-Fmoc-Nβ-diazoketone-L-2,3-diaminopropionic Acid; 1-Diazo-3-[(9H-fluoren-9-ylmethoxy)carbonyl]amino-2-butanone; Fmoc-3-amino-1-diazo-2-butanone
EINECS	Contact for details

Quality Control

Our (3S)-3-Fmoc-Amino-1-Diazo-2-Butanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The material is light-sensitive and should be handled under controlled conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.