Description

Taltirelin Hydrate is a synthetic thyrotropin-releasing hormone (TRH) analog with significant research and pharmaceutical interest. This compound matters for its enhanced metabolic stability and potent central nervous system activity compared to the endogenous hormone. It is primarily needed by pharmaceutical R&D teams and manufacturers developing treatments for neurological disorders, as well as by academic and clinical researchers studying neuroendocrinology and related pathways.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or precursor in the formulation of neurological therapeutics.
• Neurological Research: Used in preclinical and clinical studies to investigate its effects on conditions like spinocerebellar degeneration, amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases.
• Neuroendocrine Studies: A vital tool for studying the hypothalamic-pituitary-thyroid axis, TRH receptor function, and related signaling pathways.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Assays: Utilized in in vitro and in vivo assays to evaluate biological activity and receptor binding affinity.

Basic Information

Product Name	Taltirelin Hydrate
CAS No.	201677-75-0
Molecular Formula	C17H23N7O5 • xH2O
Molecular Weight	405.41 g/mol (Anhydrous basis)
Synonyms	Taltirelin; Taltirelin Monohydrate; TA-0910; (4S,5S)-5-Methyl-2-oxo-4-thiazolidinecarboxylic acid L-histidyl-L-prolinamide; L-Histidyl-L-prolinamide, N-[(4S,5S)-5-methyl-2-oxo-4-thiazolidinyl]carbonyl]-; CG-3703; YM-14673; TRH Analog TA-0910
EINECS	Contact for details

Quality Control

Our Taltirelin Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure compliance with high-grade pharmaceutical standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.