Description

1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the halogen pattern confers specific biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heteroaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries.
• Dye and Pigment Intermediate: Used in the synthesis of specialized halogenated dyes and organic pigments.

Basic Information

Product Name	1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene
CAS No.	200190-87-0
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	4-Bromo-1-Chloro-2-Fluoro-5-Methylbenzene; 2-Fluoro-5-Methyl-1-Bromo-4-Chlorobenzene; 5-Methyl-2-Fluoro-1-Bromo-4-Chlorobenzene; 1-Bromo-4-chloro-2-fluoro-5-methyl-benzene; Benzene, 1-bromo-4-chloro-2-fluoro-5-methyl-; 2-Fluoro-5-methyl-1,4-dihalobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.