Description

3-Chloro-3-Ethyldiazirine is a highly reactive, small-ring diazirine compound primarily used as a versatile photolabile crosslinking agent in advanced chemical and biochemical research. Its core value lies in its ability to generate highly reactive carbene intermediates upon photolysis, enabling the formation of covalent bonds with a wide range of organic molecules for labeling and structural studies. This product is essential for researchers and process developers in pharmaceutical discovery, materials science, and proteomics who require precise photoaffinity labeling and surface functionalization techniques.

Application

• Photoaffinity Labeling (PAL): A critical tool in drug discovery for mapping small molecule-protein interaction sites and identifying biological targets.
• Bioconjugation and Probe Synthesis: Used to create covalent crosslinks between biomolecules (e.g., proteins, nucleic acids) and reporter tags or solid supports.
• Polymer and Surface Modification: Enables the photochemical grafting of functional groups onto polymer chains or material surfaces to alter physicochemical properties.
• Proteomics Research: Facilitates the study of protein structures, dynamics, and complex formations through covalent trapping of interacting partners.
• Materials Science Crosslinking: Employed in the development of novel polymeric networks, hydrogels, and composite materials with tailored characteristics.
• Chemical Biology Tool Development: Serves as a key building block for synthesizing advanced molecular probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	3-Chloro-3-Ethyldiazirine
CAS No.	29667-77-4
Molecular Formula	C4H7ClN2
Molecular Weight	118.56 g/mol
Synonyms	3-Chloro-3-ethyldiaziridine; 3-Ethyl-3-chlorodiazirine; Diaziridine, 3-chloro-3-ethyl-; 3-Chloro-3-ethyl-diaziridine; Ethylchlorodiazirine; Photoreactive crosslinker 3C3E
EINECS	Contact for details

Quality Control

Our 3-Chloro-3-Ethyldiazirine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and relevant physical data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures between 2°C and 8°C (refrigerated) to minimize decomposition and maintain stability due to its light-sensitive and highly volatile nature. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.