Description

2-Propanone, 1,1-Difluoro-1-Phenyl- is a specialized fluorinated ketone building block, also known as α,α-Difluoroacetophenone. This compound matters for its unique reactivity profile, where the difluoromethyl ketone moiety serves as a versatile synthon in advanced organic synthesis, particularly for introducing fluorine atoms to modulate the biological activity and physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty materials and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including protease inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used to build fluorinated analogs of pesticides and herbicides to enhance their metabolic stability and efficacy.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of fluorinated polymers with specific thermal or surface properties.
• Fluorine Chemistry Reagent: Employed in nucleophilic and electrophilic fluorination reactions to construct complex fluoroorganic molecules.
• Ligand and Catalyst Development: Utilized for preparing fluorinated ligands for metal complexes used in asymmetric catalysis.

Basic Information

Product Name	2-Propanone, 1,1-Difluoro-1-Phenyl-
CAS No.	29548-91-2
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	α,α-Difluoroacetophenone; 1,1-Difluoro-1-phenylethanone; Difluoroacetophenone; Phenyldifluoromethyl ketone; 2,2-Difluoro-1-phenylethanone; (Difluoroacetyl)benzene; 1-Phenyl-1,1-difluoroacetone; EINECS 249-739-8
EINECS	249-739-8

Quality Control

Our 2-Propanone, 1,1-Difluoro-1-Phenyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flames. Ensure containers are kept tightly sealed when not in use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.