Description

D-Erythro-Methylphenidate Hydrochloride is a high-purity, stereochemically defined active pharmaceutical ingredient (API) and key intermediate. This compound is critical for research and development in neuropharmacology and for the synthesis of specialized pharmaceutical agents. It is primarily utilized by pharmaceutical manufacturers, advanced research institutions, and fine chemical synthesis companies focused on central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of advanced pharmaceutical compounds targeting neurological pathways.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Pharmacological Research: Employed in preclinical and clinical research studies investigating mechanisms of action related to CNS activity.
• Process Development: Serves as a critical intermediate in the development and scale-up of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Regulatory Submissions: Supplied as a well-characterized material to support regulatory filings (e.g., DMF, CMC sections) for new drug applications.

Basic Information

Product Name	D-Erythro-Methylphenidate Hydrochloride
CAS No.	29419-97-4
Molecular Formula	C14H19NO2·HCl
Molecular Weight	269.77 g/mol (Free base: 233.31 g/mol)
Synonyms	(2R,2'R)-Methylphenidate Hydrochloride; d-threo-Methylphenidate Hydrochloride; Dexmethylphenidate Hydrochloride; Focalin Impurity; (R,R)-Methylphenidate HCl; d-erythro-Methyl α-phenyl-2-piperidineacetate hydrochloride; 29419-97-4
EINECS	Contact for details

Quality Control

Our D-Erythro-Methylphenidate Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (d-erythro isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.