Description

3-(2-Bromoethyl)-3-Methyl-3H-Diazirine is a specialized, highly reactive heterocyclic compound featuring a diazirine ring. This compound is valued for its role as a versatile photoaffinity labeling reagent and crosslinking agent in advanced chemical and biochemical research. It is primarily sought by research institutions and pharmaceutical companies engaged in proteomics, structural biology, and materials science. The product is supplied to the global market with a focus on consistent purity and reliable performance in sensitive applications.

Application

• Photoaffinity Labeling (PAL): A critical reagent for mapping biomolecular interaction sites and identifying protein-ligand binding pockets through covalent crosslinking upon UV light activation.
• Chemical Biology & Proteomics: Used to create functionalized probes for studying protein structure, function, and dynamics within complex biological systems.
• Bioconjugation & Crosslinking: Enables the site-specific attachment of labels, tags, or other molecules to proteins, nucleic acids, or polymers for diagnostic and therapeutic development.
• Materials Science Research: Employed in surface modification and the development of novel polymeric networks where controlled, light-induced crosslinking is required.
• Pharmaceutical R&D: Integral to drug discovery efforts for target identification and validation, helping to elucidate mechanisms of action.
• Synthetic Organic Chemistry: Serves as a key intermediate or precursor for synthesizing more complex molecules with diazirine functionalities.

Basic Information

Product Name	3-(2-Bromoethyl)-3-Methyl-3H-Diazirine
CAS No.	29205-50-3
Molecular Formula	C5H9BrN2
Molecular Weight	177.04 g/mol
Synonyms	3-(2-Bromoethyl)-3-methyldiazirine; 3-Methyl-3-(2-bromoethyl)diazirine; 3H-Diazirine, 3-(2-bromoethyl)-3-methyl-; Diazirine, 3-(2-bromoethyl)-3-methyl-; 2-Bromoethyl methyl diazirine; Bromoethyldiazirine; Photoaffinity labeling reagent PAL; BEMD
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Bromoethyl)-3-Methyl-3H-Diazirine is produced and tested under stringent quality management protocols to ensure it meets the exacting standards required for research applications. Our quality control process includes comprehensive analytical characterization to verify identity, purity, and stability. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This product is light-sensitive (store away from light) and should be handled with appropriate precautions for strong acid/organic solvent compatibility. Keep container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	Clear to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 90.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.