Description

2-Chloromethylene-Malonic Acid Diethyl Ester is a versatile and reactive diester building block in organic synthesis. Its core value lies in its bifunctional structure, featuring both an activated alkene and an ester group, making it a key intermediate for constructing complex heterocycles and pharmaceutical scaffolds. This compound is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce functionalized malonate units into target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing pyridine, pyrimidine, and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require functionalized malonic acid derivatives.
• Fine Chemical Building Block: Serves as a versatile reagent for Diels-Alder reactions, Michael additions, and cyclocondensation reactions to create complex organic structures.
• Material Science Research: Employed in the development of novel polymers, ligands, and organic electronic materials due to its reactive chloromethylene group.
• Academic & Industrial R&D: A valuable tool for method development and exploring new synthetic pathways in medicinal and process chemistry laboratories.

Basic Information

Product Name	2-Chloromethylene-Malonic Acid Diethyl Ester
CAS No.	28783-51-9
Molecular Formula	C8H11ClO4
Molecular Weight	206.62 g/mol
Synonyms	Diethyl (chloromethylene)malonate; Diethyl 2-(chloromethylene)malonate; (Chloromethylene)malonic Acid Diethyl Ester; Ethyl 2-Chloro-2-(ethoxycarbonyl)acetate; NSC 403697; Chloromethylenemalonic Acid Diethyl Ester; 2-(Chloromethylene)propanedioic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our 2-Chloromethylene-Malonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.