Description

Dimethyl 3-Methyl-trans-1,2-Cyclopropanedicarboxylate is a high-purity, versatile cyclopropane derivative used as a critical chiral building block in advanced organic synthesis. Its rigid, strained three-membered ring structure and functionalized ester groups make it a valuable precursor for constructing complex molecular architectures with high stereochemical control. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce cyclopropane motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the incorporation of a functionalized cyclopropane ring to modulate biological activity and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the cyclopropane unit can enhance potency and environmental selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique thermal or mechanical properties derived from the cyclopropane structure.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, including ring-opening and cross-coupling reactions.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing specific aroma chemicals with complex, stereodefined structures.

Basic Information

Product Name	Dimethyl 3-Methyl-trans-1,2-Cyclopropanedicarboxylate
CAS No.	28363-79-3
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	trans-1,2-Cyclopropanedicarboxylic acid, 3-methyl-, dimethyl ester; Dimethyl 3-methyl-trans-1,2-cyclopropanedicarboxylate; 3-Methyl-trans-1,2-cyclopropanedicarboxylic acid dimethyl ester; Methyl 3-methyl-trans-1,2-cyclopropanedicarboxylate; (1R,2S)-rel-3-Methylcyclopropane-1,2-dicarboxylic acid dimethyl ester; (1S,2R)-rel-3-Methylcyclopropane-1,2-dicarboxylic acid dimethyl ester; Dimethyl (1R,2S)-3-methylcyclopropane-1,2-dicarboxylate
EINECS	Contact for details

Quality Control

Our Dimethyl 3-Methyl-trans-1,2-Cyclopropanedicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available for every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.