Description

4-Chloro-4'-Fluorochalcone is a high-purity, synthetic chalcone derivative characterized by its distinct halogenated aromatic structure. This compound serves as a critical pharmaceutical intermediate and a versatile organic building block for advanced chemical synthesis. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting anti-inflammatory, anticancer, and antimicrobial pathways.
• Organic Synthesis Building Block: Utilized in cyclization reactions, such as the synthesis of flavanones and pyrazolines, due to its α,β-unsaturated ketone moiety.
• Agrochemical Research: Serves as a starting material for developing new pesticides and herbicides with enhanced efficacy.
• Material Science: Investigated for use in organic light-emitting diodes (OLEDs) and non-linear optical (NLO) materials due to its conjugated system.
• Biochemical Research: Used as a standard or probe in studying enzyme inhibition and biological activity of chalcone derivatives.
• Chemical Reference Standard: Employed for analytical method development, calibration, and quality control in laboratory settings.

Basic Information

Product Name	4-Chloro-4'-Fluorochalcone
CAS No.	28081-12-1
Molecular Formula	C15H10ClFO
Molecular Weight	260.69 g/mol
Synonyms	(E)-1-(4-Chlorophenyl)-3-(4-fluorophenyl)prop-2-en-1-one; 3-(4-Fluorophenyl)-1-(4-chlorophenyl)-2-propen-1-one; 4-Chloro-4'-fluorochalcone; 4'-Fluoro-4-chlorochalcone; Chalcone, 4-chloro-4'-fluoro-; 1-(4-Chlorobenzoyl)-2-(4-fluorobenzylidene)ethane; (E)-3-(4-Fluorophenyl)-1-(4-chlorophenyl)prop-2-en-1-one
EINECS	Contact for details

Quality Control

Our 4-Chloro-4'-Fluorochalcone is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.