Description

2'-Methoxy-2,2,2-trifluoroacetophenone is a versatile fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoroacetyl and methoxy substituents, making it a critical intermediate for constructing complex molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those requiring a trifluoromethyl ketone moiety for enhanced metabolic stability or binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or liquid crystals with unique optical and electronic properties.
• Chemical Research: A valuable reagent for studying nucleophilic addition reactions and for introducing the trifluoroacetyl group into complex molecular architectures.

Basic Information

Product Name	2'-Methoxy-2,2,2-trifluoroacetophenone
CAS No.	26944-43-4
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2,2,2-Trifluoro-1-(2-methoxyphenyl)ethanone; 1-(2-Methoxyphenyl)-2,2,2-trifluoroethanone; 2-Methoxy-α,α,α-trifluoroacetophenone; o-Methoxy-α,α,α-trifluoroacetophenone; 2'-Methoxy-α,α,α-trifluoroacetophenone; 2-Methoxytrifluoroacetophenone; 1-(2-Methoxyphenyl)-2,2,2-trifluoro-1-ethanone
EINECS	Contact for details

Quality Control

Our 2'-Methoxy-2,2,2-trifluoroacetophenone is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.