Description

3-(4-(Trifluoromethyl)Phenyl)Oxetan-3-Ol is a high-value oxetane derivative featuring a trifluoromethylphenyl substituent, a structural motif of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique scaffold can impart desirable metabolic stability and lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the oxetane and trifluoromethyl groups can enhance biological activity and environmental profile.
• Material Science Precursor: Employed in the synthesis of specialized polymers, resins, and liquid crystals that require rigid, polar building blocks for tailored physical properties.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes and tool compounds used in biochemical and pharmacological research.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl and conjugated systems.
• Fragment-Based Drug Discovery (FBDD): Utilized as a privileged fragment in FBDD libraries due to its three-dimensionality and potential for high ligand efficiency.

Basic Information

Product Name	3-(4-(Trifluoromethyl)Phenyl)Oxetan-3-Ol
CAS No.	26755-29-3
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	3-[4-(Trifluoromethyl)phenyl]oxetan-3-ol; 3-Hydroxy-3-[4-(trifluoromethyl)phenyl]oxetane; 3-(4-Trifluoromethylphenyl)-3-oxetanol; 3-(p-Trifluoromethylphenyl)oxetan-3-ol; Oxetan-3-ol, 3-[4-(trifluoromethyl)phenyl]-; α-(Trifluoromethyl)benzenemethanol, α,α-dimethyloxetanyl-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3-(4-(Trifluoromethyl)Phenyl)Oxetan-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process development. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and physical characteristics are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.