Description

5-Phenyl-2,3,4-trimethyl-1,3,2-oxazaborolidine is a specialized heterocyclic organoboron compound that serves as a highly effective chiral catalyst and reagent in asymmetric synthesis. Its value lies in enabling the production of enantiomerically pure intermediates, which are critical for the development of pharmaceuticals and advanced materials. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking to optimize stereoselective transformations.

Application

• Asymmetric Catalysis: As a chiral Lewis acid catalyst for enantioselective Diels-Alder, aldol, and reduction reactions.
• Pharmaceutical Intermediates: Key reagent in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators.
• Material Science: Building block for novel chiral polymers and liquid crystals with specific optical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic and medicinal chemistry laboratories.
• Scale-up Process Development: Employed in pilot plants and manufacturing to establish robust, stereocontrolled production routes.

Basic Information

Product Name	5-Phenyl-2,3,4-Trimethyl-1,3,2-Oxazaborolidine
CAS No.	26535-26-2
Molecular Formula	C12H16BNO
Molecular Weight	201.08 g/mol
Synonyms	2,3,4-Trimethyl-5-phenyl-1,3,2-oxazaborolidine; 5-Phenyl-2,3,4-trimethyl-2,3-dihydro-1H-1,3,2-oxazaborole; Oxazaborolidine, 5-phenyl-2,3,4-trimethyl-; (R)- or (S)-5-Phenyl-2,3,4-trimethyl-1,3,2-oxazaborolidine (chiral forms); CBS Catalyst derivative; Corey-Bakshi-Shibata reagent analog; Chiral oxazaborolidine catalyst.
EINECS	Contact for details

Quality Control

Every batch of our 5-Phenyl-2,3,4-trimethyl-1,3,2-oxazaborolidine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and consistent performance. Our quality assurance protocol includes identity confirmation, purity assay, and control of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (for specified enantiomer)
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.