Description

2,4-Dimethyl-5-Phenyl-1,3,2-Oxazaborolidine is a specialized organoboron compound that serves as a versatile chiral reagent and catalyst. Its value lies in enabling highly stereoselective transformations, which are critical for producing enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for asymmetric synthesis.

Application

• Asymmetric Catalysis: Employed as a chiral catalyst or catalyst precursor in enantioselective reductions, such as the borane-mediated reduction of prochiral ketones.
• Pharmaceutical Intermediates: A key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and pesticides where specific stereochemistry is required for biological activity.
• Material Science: Acts as a precursor or modifying agent in the development of boron-containing polymers and advanced organic electronic materials.
• Academic & Industrial Research: A valuable tool for methodological development in organic synthesis and for exploring new asymmetric reaction pathways.
• Chiral Auxiliary: Can be used to temporarily impart chirality during multi-step synthetic sequences, later removed to yield the desired enantiopure product.

Basic Information

Product Name	2,4-Dimethyl-5-Phenyl-1,3,2-Oxazaborolidine
CAS No.	26535-23-9
Molecular Formula	C11H14BNO
Molecular Weight	187.05 g/mol
Synonyms	5-Phenyl-2,4-dimethyl-1,3,2-oxazaborolidine; (4S,5S)-(-)-2,4-Dimethyl-5-phenyl-1,3,2-oxazaborolidine; (R,R)-2,4-Dimethyl-5-phenyl-1,3,2-oxazaborolidine; Corey's Oxazaborolidine Catalyst; CBS Catalyst (Corey-Bakshi-Shibata Catalyst) derivative; Chiral Oxazaborolidine; 1,3,2-Oxazaborolidine, 2,4-dimethyl-5-phenyl-
EINECS	Contact for details

Quality Control

Our 2,4-Dimethyl-5-Phenyl-1,3,2-Oxazaborolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and NMR spectroscopy, to ensure it meets the high standards required for asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and allowed to equilibrate to room temperature before opening to prevent condensation and hydrolysis. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.