Description

(R)-2-Hydroxy-2-[(4R,5S)-4-[(R)-2-Hydroxypropyl]-5-Methyl-2-Oxo-1,3-Dioxolan-4-Yl]Acetaldehyde is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. Its complex, multi-functional structure makes it a critical intermediate for constructing sophisticated molecules with precise three-dimensional architecture. This compound is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs), complex natural products, and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel APIs, particularly in therapeutic areas requiring high stereochemical purity.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic and stoichiometric asymmetric reactions to introduce multiple stereocenters.
• Natural Product Synthesis: Serves as a building block for the total synthesis of complex natural products with intricate polyol or lactone motifs.
• Ligand and Catalyst Development: Provides a scaffold for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where specific stereochemistry is crucial for function.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and for exploring new chemical space in drug discovery programs.

Basic Information

Product Name	(R)-2-Hydroxy-2-[(4R,5S)-4-[(R)-2-Hydroxypropyl]-5-Methyl-2-Oxo-1,3-Dioxolan-4-Yl]Acetaldehyde
CAS No.	26428-87-5
Molecular Formula	C10H16O6
Molecular Weight	232.23 g/mol
Synonyms	(R)-2-Hydroxy-2-[(4R,5S)-4-[(R)-2-Hydroxypropyl]-5-methyl-2-oxo-1,3-dioxolan-4-yl]acetaldehyde; 4-(1,2-Dihydroxyethyl)-4-(1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde; (4R,5S)-4-[(1R)-1,2-Dihydroxyethyl]-4-(1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde; D-Glycero-D-ido-Heptose Derivative; Chiral Dioxolane Aldehyde; (R)-Configured Lactaldehyde Derivative
EINECS	Contact for details

Quality Control

Our production of (R)-2-Hydroxy-2-[(4R,5S)-4-[(R)-2-Hydroxypropyl]-5-Methyl-2-Oxo-1,3-Dioxolan-4-Yl]Acetaldehyde adheres to stringent quality management protocols to ensure batch-to-batch consistency and high enantiomeric excess. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), identity, and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.