Description

Dehydroretronecine is a pyrrolizidine alkaloid (PA) derivative and a key chemical intermediate in the synthesis of more complex alkaloids and for biochemical research. Its precise structure makes it a valuable reference standard and building block for investigating the metabolism and toxicity of pyrrolizidine alkaloids, which are of significant concern in food safety, phytochemistry, and toxicology. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical testing industries who require high-purity intermediates for synthesis or certified reference materials for analysis.

Application

• Pharmaceutical Research Intermediate: Serves as a critical precursor in the synthesis and study of pyrrolizidine alkaloids and their analogs for pharmacological investigation.
• Analytical Reference Standard: Used as a high-purity certified reference material (CRM) in HPLC, LC-MS, and GC-MS methods for the identification and quantification of pyrrolizidine alkaloids in herbal products, supplements, and food.
• Toxicology and Metabolism Studies: Employed in research to understand the bioactivation, metabolic pathways, and hepatotoxic mechanisms of pyrrolizidine alkaloids.
• Phytochemistry and Natural Product Isolation: Acts as a standard for the isolation, characterization, and structural elucidation of related alkaloids from plant extracts.
• Biochemical Probe Development: Utilized in developing probes and assays to study enzyme interactions specific to pyrrolizidine alkaloid metabolism.
• Agrochemical Research: Investigated as a lead compound or intermediate for developing novel bioactive molecules.

Basic Information

Product Name	Dehydroretronecine
CAS No.	26400-45-3
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	7,9-Didehydroretronecine; (1R,7aR)-1-Hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-one; DHR; Dehydroretronecin; 1-Hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-one; Retronecine derivative
EINECS	Contact for details

Quality Control

Our Dehydroretronecine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.