Description

(14R)-2β,3β-Epoxygrayanotoxane-5,6β,10,14,16-Pentol 6-Acetate is a specific, high-purity diterpenoid derivative belonging to the grayanotoxin family, a class of compounds known for their complex polycyclic structures and significant bioactivity. This compound is valued as a critical reference standard and advanced research intermediate for pharmacological and toxicological studies. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and analytical testing facilities focused on neuroactive natural products, ion channel modulation, and the synthesis of novel bioactive molecules.

Application

• Pharmacological Research: Serves as a key reference material and active pharmaceutical ingredient (API) intermediate in studies investigating sodium channel modulation and neurotoxicity mechanisms.
• Analytical Standard: Used as a certified reference standard (CRS) for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of grayanotoxin-related compounds in complex matrices.
• Natural Product Chemistry: Acts as a sophisticated building block or precursor for the semi-synthesis of novel diterpenoid analogs with potential therapeutic applications.
• Toxicology Studies: Employed in controlled laboratory studies to understand the specific toxicokinetics and metabolic pathways of grayanotoxin derivatives.
• Academic & Institutional Research: Supports fundamental research in chemical biology, medicinal chemistry, and plant toxin characterization.

Basic Information

Product Name	(14R)-2β,3β-Epoxygrayanotoxane-5,6β,10,14,16-Pentol 6-Acetate
CAS No.	26116-89-2
Molecular Formula	C22H34O8
Molecular Weight	426.51 g/mol
Synonyms	Grayanotoxin XVIII 6-acetate; 6-Acetoxygrayanotoxin XVIII; (14R)-2β,3β-Epoxygrayanotoxane-5β,6β,10,14,16-pentol 6-acetate; 2β,3β-Epoxy-5β,6β,10,14,16-pentahydroxygrayanotoxan-6-yl acetate; Grayanotoxin XVIII acetate; Grayanotoxin derivative 6-O-acetate; 6-O-Acetyl-2,3-epoxygrayanotoxane-5,6,10,14,16-pentol
EINECS	Contact for details

Quality Control

Our (14R)-2β,3β-Epoxygrayanotoxane-5,6β,10,14,16-Pentol 6-Acetate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and integrity. Each lot undergoes comprehensive analytical characterization, including HPLC purity assay, structural confirmation (NMR, MS), and identity verification (IR). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support research and development with material traceable to reliable sourcing and validated analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.