Description

(E)-β-Chloro-4'-Iodoacrylophenone is a high-purity, halogenated α,β-unsaturated ketone building block of significant interest in synthetic organic chemistry. Its unique structure, featuring both chlorine and iodine substituents on a reactive acrylophenone scaffold, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other biological pathways where halogenated motifs are critical.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its reactive double bond and halogen atoms for further functionalization.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the research and development of specialty polymers and advanced organic materials.
• Chemical Biology Probe Synthesis: Employed to create tagged or labeled molecules for studying biological processes and protein interactions.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, including cross-coupling reactions and cycloadditions.

Basic Information

Product Name	(E)-β-Chloro-4'-Iodoacrylophenone
CAS No.	25872-00-8
Molecular Formula	C9H6ClIO
Molecular Weight	292.50 g/mol
Synonyms	(E)-3-Chloro-1-(4-iodophenyl)-2-propen-1-one; 3-Chloro-1-(4-iodophenyl)-2-propen-1-one; 4'-Iodo-3-chloroacrylophenone; β-Chloro-4'-iodochalcone; 1-(4-Iodophenyl)-3-chloroprop-2-en-1-one; (E)-3-Chloro-1-(4-iodophenyl)prop-2-en-1-one
EINECS	Contact for details

Quality Control

Our (E)-β-Chloro-4'-Iodoacrylophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.