Description

4-(Methoxymethoxy)Bromobenzene is a versatile aryl bromide building block featuring a protected hydroxymethyl group. This compound is crucial for organic synthesis, particularly in cross-coupling reactions like Suzuki and Negishi couplings, where it serves as a key electrophilic component. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex aromatic and heteroaromatic structures. The product is supplied with a high level of purity to ensure consistent performance in sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring functionalized biphenyl or aryl ether motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the bromobenzene core is a critical structural element.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Cross-Coupling Reactions: An essential electrophile in palladium-catalyzed coupling reactions (e.g., Suzuki, Stille, Kumada) to form biaryl and other C-C bonds.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes.

Basic Information

Product Name	4-(Methoxymethoxy)Bromobenzene
CAS No.	25458-45-1
Molecular Formula	C9H11BrO2
Molecular Weight	231.09 g/mol
Synonyms	1-Bromo-4-(methoxymethoxy)benzene; p-(Methoxymethoxy)bromobenzene; 4-Bromophenyl methoxymethyl ether; (4-Bromophenoxy)methoxymethane; MOM-protected 4-bromophenol; Bromobenzene, 4-(methoxymethoxy)-; 25458-45-1; 4-Bromo-1-(methoxymethoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-(Methoxymethoxy)Bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We adhere to relevant industry standards and can support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.