Description

4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Ol is a versatile organoboron compound, specifically a cyclic boronic ester derivative, valued for its role as a key synthetic intermediate. Its primary commercial importance lies in its application as a crucial building block in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for carbon-carbon bond formation. This product is essential for industries engaged in the research and production of pharmaceuticals, agrochemicals, and advanced organic materials, where precise molecular construction is required.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science: Serves as a monomer or precursor in the creation of organic electronic materials, such as polymers for OLEDs and semiconductors.
• Chemical Research & Development: A standard tool in academic and industrial R&D labs for constructing complex organic molecules and exploring new synthetic pathways.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts.
• Fine Chemical Production: Integral to the manufacture of dyes, flavors, and fragrances that incorporate boronate ester functionalities.

Basic Information

Product Name	4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Ol
CAS No.	25240-59-9
Molecular Formula	C6H13BO3
Molecular Weight	143.98 g/mol
Synonyms	2-Hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol Boronic Ester; Pinacol Boronate; 2-Hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacolato Boronic Acid; (4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)oxidanyl; Boric acid, cyclic ester with pinacol
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for synthetic intermediate applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.