Description

1,1,1,3,3,3-Hexafluoro-2-Propyl Mesylate is a specialized fluorinated mesylate ester, a key building block in advanced organic synthesis. Its primary value lies in its role as a versatile electrophilic reagent for introducing the hexafluoroisopropoxy (HFIP) group, a moiety known for dramatically altering the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for developing novel compounds with enhanced metabolic stability, lipophilicity, or unique electronic characteristics.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs) containing the hexafluoroisopropyl (HFIP) group, which can improve drug potency, bioavailability, and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and polymerization reactions.
• Advanced Material Production: Employed in the manufacture of fluorinated polymers, liquid crystals, and electronic materials to impart high thermal stability, chemical resistance, and unique optical properties.
• Proteolysis-Targeting Chimera (PROTAC) Linker Chemistry: Utilized in the construction of bifunctional molecules for targeted protein degradation, a cutting-edge therapeutic modality.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new fluorination methodologies and the structure-activity relationships of fluorinated compounds.

Basic Information

Item	Detail
Product Name	1,1,1,3,3,3-Hexafluoro-2-Propyl Mesylate
CAS No.	25236-65-1
Molecular Formula	C7H8F6O3S
Molecular Weight	286.19 g/mol
Synonyms	Hexafluoroisopropyl Methanesulfonate; HFIP Mesylate; 1,1,1,3,3,3-Hexafluoropropan-2-yl Methanesulfonate; 2-(Methanesulfonyloxy)-1,1,1,3,3,3-hexafluoropropane; 1,1,1,3,3,3-Hexafluoro-2-propanol Methanesulfonate; Hexafluoroisopropanol Mesylate; HFIP-OMs
EINECS	Contact for details

Quality Control

Our 1,1,1,3,3,3-Hexafluoro-2-Propyl Mesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support compliance with relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.