Description

12-Deoxyphorbol 13-Isobutyrate is a bioactive diterpene ester belonging to the phorbol family, a class of compounds known for their potent biological activity. This specific derivative is a critical reference standard and intermediate in pharmaceutical research, particularly for studying protein kinase C (PKC) modulation and related signal transduction pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity, well-characterized compounds for drug discovery and biochemical studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of related compounds in drug development and quality control laboratories.
• Biochemical Research: Serves as a key tool compound for investigating the structure-activity relationships (SAR) of phorbol esters and their interaction with protein kinase C (PKC) isoforms.
• Drug Discovery Intermediate: Acts as a sophisticated synthetic building block or precursor for the development of novel therapeutic agents targeting PKC-related pathways.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, oncology, and toxicology related to tumor promotion and cellular signaling.
• Analytical Method Development: Employed to develop and validate chromatographic methods (e.g., HPLC, LC-MS) for the detection and quantification of diterpene esters in complex matrices.

Basic Information

Product Name	12-Deoxyphorbol 13-Isobutyrate
CAS No.	25090-74-8
Molecular Formula	C26H36O6
Molecular Weight	444.56 g/mol
Synonyms	12-Deoxyphorbol 13-isobutyrate; 12-Deoxyphorbol 13-(2-methylpropanoate); 4,9,12,13-Tetrahydroxy-1,6-tigliadien-3-one 13-isobutyrate; Phorbol 12-deoxy-13-isobutyrate; NSC 326322; 13-Isobutyryl-12-deoxyphorbol
EINECS	Contact for details

Quality Control

Our 12-Deoxyphorbol 13-Isobutyrate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by high-performance liquid chromatography (HPLC). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.