Description

3-(3-Methyl-3H-Diazirine-3-Yl)Propionic Acid is a specialized heterocyclic carboxylic acid featuring a reactive diazirine ring, making it a valuable photoactivatable crosslinking agent. This compound is essential for advanced biochemical research and materials science, enabling the study of biomolecular interactions and the development of functionalized surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and polymer chemistry sectors who require precise, light-induced covalent bonding capabilities.

Application

• Photoaffinity Labeling (PAL): A critical tool in proteomics and drug discovery for identifying and mapping transient protein-ligand and protein-protein interactions.
• Bioconjugation & Probe Synthesis: Used to create photoactivatable probes, tags, and linkers for labeling antibodies, peptides, and other biomolecules.
• Surface Functionalization: Enables the covalent attachment of biomolecules or polymers to surfaces (e.g., chips, nanoparticles, beads) under controlled UV light exposure for biosensor and diagnostic device development.
• Polymer & Materials Science: Serves as a crosslinker or monomer for synthesizing smart polymers and hydrogels with light-responsive properties.
• Chemical Biology Research: Facilitates the study of metabolic pathways and enzyme mechanisms by irreversibly trapping active intermediates.

Basic Information

Product Name	3-(3-Methyl-3H-Diazirine-3-Yl)Propionic Acid
CAS No.	25055-86-1
Molecular Formula	C6H8N2O2
Molecular Weight	140.14 g/mol
Synonyms	3-(3-Methyldiazirin-3-yl)propanoic acid; 3-[3-Methyl-3H-diazirin-3-yl]propanoic acid; 3-(3-Methyldiaziridin-3-yl)propionic acid; Diazirine-3-propionic acid, 3-methyl-; Photoactivatable crosslinker; PAL reagent; ADHP (3-Azibutyl)propionic acid derivative; Light-sensitive carboxylic acid crosslinker.
EINECS	Contact for details

Quality Control

Our 3-(3-Methyl-3H-Diazirine-3-Yl)Propionic Acid is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, which is critical for reproducible research and development outcomes. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in regulated and non-regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its strictly light-sensitive and hygroscopic nature, this material must be stored in opaque, moisture-proof containers under an inert atmosphere (e.g., argon or nitrogen) at recommended temperatures of -20°C or below for long-term stability. The storage area should be cool, dry, and well-ventilated. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.