Description

4-Chloroisothiazole is a versatile and high-value halogenated heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Its reactive chlorinated isothiazole core makes it indispensable for researchers and manufacturers creating active ingredients, functional materials, and specialty chemicals. The product is supplied as 4-Chloroisothiazole CAS NO 25039-53-6, meeting the stringent purity requirements of industrial and R&D applications.

Application

• Pharmaceutical Intermediates: Key synthon for the synthesis of novel drug candidates, including antimicrobials, antivirals, and central nervous system (CNS) active compounds.
• Agrochemical Active Ingredients: Building block for developing next-generation fungicides, herbicides, and insecticides with improved efficacy and environmental profiles.
• Material Science & Functional Chemicals: Used in the production of dyes, pigments, photographic chemicals, and polymers requiring specific heterocyclic functionalities.
• Organic Synthesis & Research: A fundamental reagent for constructing complex isothiazole derivatives, facilitating research in medicinal chemistry and chemical biology.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Chloroisothiazole
CAS No.	25039-53-6
Molecular Formula	C3H2ClNS
Molecular Weight	119.57 g/mol
Synonyms	4-Chloro-1,2-thiazole; 4-Chloro-isothiazole; Isothiazole, 4-chloro-; 4-Chlorothiazole (common misnomer); 4-Cl-isothiazole; 4-Chloro-1λ4,2-thiazole; 25039-53-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-Chloroisothiazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) detailing purity, identity, and impurity profiles verified by techniques such as GC, HPLC, and NMR. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere if long-term storage is required to minimize potential degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.