Description

Spiramycin I is a major component of the spiramycin antibiotic complex, a 16-membered macrolide produced by *Streptomyces ambofaciens*. This compound is valued for its potent antibacterial activity, particularly against Gram-positive bacteria and certain intracellular pathogens. It serves as a critical pharmaceutical reference standard and active pharmaceutical ingredient (API) for research, quality control, and the development of therapeutic formulations in the human and veterinary sectors.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of spiramycin in pharmacopoeial testing (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API): A key component in the manufacture of antibiotic formulations for clinical use.
• Veterinary Medicine: Employed in treatments for bacterial infections in livestock and companion animals.
• Microbiological Research: Serves as a tool compound for studying macrolide antibiotic mechanisms of action and bacterial resistance.
• Quality Control & Analytical Development: Essential for calibrating HPLC, LC-MS, and other analytical instruments in QC laboratories.
• Biosynthesis Studies: Used in research focused on the metabolic engineering of antibiotic-producing microorganisms.

Basic Information

Product Name	Spiramycin I
CAS No.	24916-50-5
Molecular Formula	C43H74N2O14
Molecular Weight	843.06 g/mol
Synonyms	Spiramycin A1; Foromacidin A; Sequamycin; Rovamycin component I; Antibiotic 5337 component I; Provamycin; (3R,4S,5S,6R,8R,9R,10E,12E,15R)-5-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-9-ethyl-4-hydroxy-6,8,10,12-tetramethyl-15-[(2R,5S,6R)-5-methyl-5-(4-methyloxan-2-yl)oxyoxan-2-yl]oxyoxacyclopentadeca-10,12-diene-2,3-dione
EINECS	246-522-1

Quality Control

Our Spiramycin I is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, purity, and related substances as determined by validated analytical methods (e.g., HPLC). We support compliance with major pharmacopoeial standards (USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.