Description

Ethyl 3-(Trifluoromethyl)Crotonate is a high-value fluorinated building block characterized by its reactive α,β-unsaturated ester functionality. This compound is essential for introducing the trifluoromethyl group into complex molecular architectures, a key modification for enhancing metabolic stability and lipophilicity in advanced materials and pharmaceuticals. It is primarily sought after by R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty chemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, particularly those requiring the bioisosteric trifluoromethyl group to improve pharmacokinetic properties.
• Agrochemical Active Ingredient Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group contributes to efficacy and environmental stability.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating fluorinated polymers with unique surface properties, chemical resistance, and durability.
• Organic Synthesis & Catalysis: Employed in Michael additions, Diels-Alder reactions, and other C-C bond-forming transformations to construct complex fluorinated molecules.
• Liquid Crystal & Electronic Chemical Precursor: Used in the development of fluorinated components for display technologies and electronic materials.

Basic Information

Product Name	Ethyl 3-(Trifluoromethyl)Crotonate
CAS No.	24490-03-7
Molecular Formula	C7H9F3O2
Molecular Weight	182.14 g/mol
Synonyms	Ethyl (E)-3-(Trifluoromethyl)but-2-enoate; (E)-Ethyl 3-(Trifluoromethyl)crotonate; 2-Butenoic acid, 3-(trifluoromethyl)-, ethyl ester; Ethyl (E)-3-(trifluoromethyl)-2-butenoate; Ethyl β-Trifluoromethylcrotonate; TFMC Ethyl Ester; 3-(Trifluoromethyl)crotonic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-(Trifluoromethyl)Crotonate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its sensitivity to strong bases and fluorophilic reagents, store separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Isomeric Purity (E/Z Ratio)	≥ 95:5 (E/Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.