Description

4-Bromo-1-(Chloromethyl)-2-Methylbenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both bromo and chloromethyl substituents on a methylbenzene core, makes it a critical precursor for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, polymer modification, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key starting material for the synthesis of complex drug molecules, particularly in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the halogenated aromatic ring is incorporated into the active ingredient.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized phosphine ligands or metal-organic frameworks (MOFs) used in catalysis.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for modifying the properties of specialty polymers and resins.
• Material Science Research: Utilized in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Fine Chemical Production: Acts as a building block for dyes, pigments, and other high-value specialty chemicals.

Basic Information

Product Name	4-Bromo-1-(Chloromethyl)-2-Methylbenzene
CAS No.	24078-15-7
Molecular Formula	C8H8BrCl
Molecular Weight	219.51 g/mol
Synonyms	1-Bromo-4-(chloromethyl)-3-methylbenzene; 2-Methyl-4-bromobenzyl chloride; 4-Bromo-2-methylbenzyl chloride; (4-Bromo-2-methylphenyl)methyl chloride; α-Chloro-4-bromo-2-methyltoluene; 4-Bromo-o-tolylmethyl chloride; 2-Methyl-4-bromobenzylchloride; 4-Bromo-2-methylbenzylchloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Chloromethyl)-2-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.