Description

2,4-Dichloropyrimidine-5-Sulfonyl Chloride is a high-value, multi-functional chemical building block characterized by its reactive sulfonyl chloride and chlorinated pyrimidine moieties. This compound is essential for the efficient synthesis of complex molecules, enabling the rapid introduction of sulfonamide and heterocyclic functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Synthesis: Used to construct novel herbicidal and fungicidal agents by incorporating the dichloropyrimidine scaffold into active molecules.
• Material Science Research: Serves as a building block for creating functionalized polymers and advanced organic materials with specific electronic properties.
• Chemical Biology Probes: Employed in the development of activity-based probes and covalent inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2,4-Dichloropyrimidine-5-Sulfonyl Chloride
CAS No.	23920-08-3
Molecular Formula	C4Cl3N2O2S
Molecular Weight	261.48 g/mol
Synonyms	5-(Chlorosulfonyl)-2,4-dichloropyrimidine; 2,4-Dichloro-5-pyrimidinesulfonyl chloride; Pyrimidine-5-sulfonyl chloride, 2,4-dichloro-; 2,4-Dichloropyrimidine-5-sulfonylchloride; 23920-08-3; 2,4-Dichloro-5-sulfonylchloropyrimidine
EINECS	Contact for details

Quality Control

Our 2,4-Dichloropyrimidine-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.