Description

3-(3,3-Diethoxypropyl)-3-Methyl-3H-Diazirine CAS NO 23902-18-3 is a specialized diazirine-based photoaffinity labeling reagent. This compound is valued for its ability to generate highly reactive carbene intermediates upon photolysis with UV light, enabling the covalent cross-linking of biomolecules for structural and interaction studies. It is primarily needed by researchers and manufacturers in the life sciences sector, particularly in pharmaceutical R&D, proteomics, and chemical biology for mapping protein-ligand interactions and active sites.

Application

• Photoaffinity Labeling (PAL): A critical tool in chemical biology for covalently tagging and identifying biological targets, such as proteins and nucleic acids.
• Proteomics Research: Used to study protein-protein interactions, protein structure, and the identification of binding sites for drug discovery.
• Bioconjugation & Probe Synthesis: Serves as a key intermediate for synthesizing advanced molecular probes and cross-linkers.
• Material Science Surface Modification: Applied in the functionalization of surfaces and polymers through photochemical grafting.
• Pharmaceutical Development: Employed in the early-stage development of new therapeutic agents to understand mechanism of action.

Basic Information

Product Name	3-(3,3-Diethoxypropyl)-3-Methyl-3H-Diazirine
CAS No.	23902-18-3
Molecular Formula	C9H18N2O2
Molecular Weight	186.25 g/mol
Synonyms	3-Methyl-3-(3,3-diethoxypropyl)diazirine; 3-(3,3-Diethoxypropyl)-3-methyldiazirine; 3-Methyl-3-(3,3-diethoxypropyl)-3H-diazirine; Diazirine, 3-(3,3-diethoxypropyl)-3-methyl-; Photoaffinity Labeling Reagent 23902-18-3; 3H-Diazirine, 3-(3,3-diethoxypropyl)-3-methyl-; PAL Reagent; Carbene Precursor
EINECS	Contact for details

Quality Control

Our 3-(3,3-Diethoxypropyl)-3-Methyl-3H-Diazirine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maximize stability. Due to its highly volatile and strictly light-sensitive nature, allow the container to reach room temperature before opening to minimize moisture ingress and decomposition. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.