Description

2,2-Dimethyl-4(S)-4-Iodomethyl-1,3-Dioxalane is a high-value chiral building block and versatile synthetic intermediate. Its core value lies in its protected iodomethyl functionality, which enables efficient carbon-carbon bond formation and the introduction of complex molecular fragments under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), nucleoside analogs, and other complex chiral molecules.

Application

• Pharmaceutical Synthesis: A key chiral intermediate for constructing complex molecules in API development, especially for antiviral and anticancer agents.
• Nucleoside Chemistry: Used in the preparation of modified nucleosides and nucleotides for medicinal chemistry and biochemical research.
• Fine Chemical Production: Serves as a versatile building block for synthesizing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Agrochemical Research: Employed in the development of advanced, chiral active ingredients for crop protection products.
• Material Science: Potential monomer or precursor for creating specialized polymers with unique properties.
• Academic & R&D: A valuable reagent for methodological studies in organic synthesis, asymmetric catalysis, and total synthesis projects.

Basic Information

Product Name	2,2-Dimethyl-4(S)-4-Iodomethyl-1,3-Dioxalane
CAS No.	23735-44-6
Molecular Formula	C6H11IO2
Molecular Weight	242.06 g/mol
Synonyms	(4S)-4-(Iodomethyl)-2,2-dimethyl-1,3-dioxolane; (S)-4-Iodomethyl-2,2-dimethyl-1,3-dioxolane; (S)-2,2-Dimethyl-4-iodomethyl-1,3-dioxolane; (S)-(-)-2,2-Dimethyl-4-iodomethyl-1,3-dioxolane; (S)-Glycerol Acetonide Iodide; (S)-1,2-Isopropylidene glycerol 3-iodide; (S)-3-Iodo-1,2-O-isopropylidene glycerol; (S)-Solketal Iodide
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-4(S)-4-Iodomethyl-1,3-Dioxalane is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical purity, verified by techniques such as HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing all specifications is available for every batch upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, the container should be amber-colored or kept in secondary opaque packaging. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (ee)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.