Description

[1R,(-)]-1α-(2-Methylenepropanoyl)-7β,7Aβ-Dimethyl-2,3,5,6,7,7A-Hexahydro-1H-Indene is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its complex, functionalized indane core structure, which serves as a versatile chiral building block for the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors seeking to construct complex molecular architectures with precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used as a building block for developing new, stereoselective pesticides and herbicides with enhanced efficacy and environmental profiles.
• Asymmetric Catalysis Research: Serves as a sophisticated ligand precursor or a test substrate for developing and screening new chiral catalysts and synthetic methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Material Science Research: Potential monomer or precursor for creating novel polymers and advanced organic materials with tailored properties.

Basic Information

Product Name	[1R,(-)]-1α-(2-Methylenepropanoyl)-7β,7Aβ-Dimethyl-2,3,5,6,7,7A-Hexahydro-1H-Indene
CAS No.	23538-45-6
Molecular Formula	C15H22O
Molecular Weight	218.33 g/mol
Synonyms	(-)-1R-1α-(2-Methylenepropanoyl)-7β,7aβ-dimethyl-2,3,5,6,7,7a-hexahydro-1H-indene; (1R)-1α-(2-Methylenepropanoyl)-7β,7aβ-dimethyl-2,3,5,6,7,7a-hexahydro-1H-indene; 1H-Indene, 1-(2-methyl-1-oxo-2-propen-1-yl)-2,3,3a,4,5,6,7,7a-octahydro-3a,7a-dimethyl-, (1R,3aR,7aS)-; (1R,3aR,7aS)-1-(2-Methylenepropanoyl)-3a,7a-dimethyl-octahydro-1H-indene; Chiral Indane Ester Derivative; Light-sensitive Indane Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, chiral analysis, and NMR spectroscopy to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and scale-up activities under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.