Description

2,2,2-Trifluoro-1-(4-Iodo-Phenyl)-Ethanone is a high-value fluorinated and iodinated aromatic ketone building block. This compound is critical for advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals, where its unique trifluoromethyl and iodo substituents enable precise molecular modifications. It is primarily sought by research institutions and industrial R&D departments engaged in medicinal chemistry, material science, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system and metabolic diseases.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethyl group.
• Material Science: Serves as a building block for advanced organic materials, including liquid crystals and polymers with specific optical or electronic properties.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry: Essential for introducing the trifluoromethylacetyl group into target molecules, a common strategy to enhance metabolic stability and lipophilicity in drug candidates.
• Chemical Synthesis Reference Standard: Used as a pure standard in analytical laboratories for method development and quality control.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-Iodo-Phenyl)-Ethanone
CAS No.	23516-84-9
Molecular Formula	C8H4F3IO
Molecular Weight	300.02 g/mol
Synonyms	4'-Iodo-2,2,2-trifluoroacetophenone; 1-(4-Iodophenyl)-2,2,2-trifluoroethanone; p-Iodophenyl trifluoromethyl ketone; 4-Iodophenyl trifluoromethyl ketone; α,α,α-Trifluoro-4'-iodoacetophenone; Trifluoro(4-iodophenyl)methanone; 2,2,2-Trifluoro-1-(4-iodophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(4-Iodo-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.