Description

1-(3-Aminophenyl)-2,2,2-Trifluoroethanone is a versatile aromatic trifluoromethyl ketone building block featuring both an amine and a ketone functional group. This bifunctional nature makes it a critical intermediate for synthesizing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research institutions and industrial manufacturers for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Functional Material Research: Employed in the development of organic electronic materials, liquid crystals, and polymers requiring specific optical or electronic properties.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing novel dyes, pigments, and fluorescent markers.
• Cross-Coupling Reactions: The aromatic amine group makes it suitable for palladium-catalyzed cross-coupling reactions to construct more complex biaryl structures.

Basic Information

Product Name	1-(3-Aminophenyl)-2,2,2-Trifluoroethanone
CAS No.	23516-80-5
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	3'-Amino-2,2,2-trifluoroacetophenone; 3-Aminophenyl trifluoromethyl ketone; 1-(3-Aminophenyl)-2,2,2-trifluoroethan-1-one; 3-Amino-α,α,α-trifluoroacetophenone; m-Aminophenyl trifluoromethyl ketone; 3-Trifluoroacetylphenylamine; 3-Amino-α,α,α-trifluoroacetophenone; 1-(3-Aminophenyl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality management system is designed to meet the stringent requirements of pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.