Description

5-Chloro-2-Hydroxy-4-Methylbenzenesulfonyl Fluoride is a specialized organosulfur compound featuring a sulfonyl fluoride functional group, a key reactive handle in modern synthetic chemistry. This compound is valued for its role as a versatile building block in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on sulfonamide-based active ingredients, novel chemical probes, and advanced material precursors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides that leverage the sulfonamide moiety for bioactivity.
• Chemical Biology Probe Development: The reactive sulfonyl fluoride group enables its use in activity-based protein profiling (ABPP) and covalent inhibitor discovery.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functionalized surfaces.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring this specific sulfonyl fluoride derivative.

Basic Information

Product Name	5-Chloro-2-Hydroxy-4-Methylbenzenesulfonyl Fluoride
CAS No.	23378-97-4
Molecular Formula	C7H6ClFO3S
Molecular Weight	224.64 g/mol
Synonyms	4-Methyl-5-chloro-2-hydroxybenzenesulfonyl Fluoride; 2-Hydroxy-4-methyl-5-chlorobenzenesulfonyl Fluoride; 5-Chloro-4-methyl-2-hydroxybenzenesulfonyl Fluoride; 5-Chloro-2-hydroxy-p-toluenesulfonyl Fluoride; 4-Methyl-5-chlorosalicylic acid sulfonyl fluoride; 23378-97-4; Benzenesulfonyl fluoride, 5-chloro-2-hydroxy-4-methyl-
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-2-Hydroxy-4-Methylbenzenesulfonyl Fluoride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets exacting R&D and process chemistry standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.