Description

1-Chloro-1-(4-Fluorophenyl)Propan-2-One is a versatile fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a reactive α-chloroketone moiety and a fluorinated aromatic ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems and β-amino ketone backbones.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological systems, leveraging the fluorine atom as an NMR-active label.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Chloro-1-(4-Fluorophenyl)Propan-2-One
CAS No.	23211-68-9
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	4'-Fluorophenacyl Chloride; 2-Chloro-1-(4-fluorophenyl)ethanone; 1-Chloro-1-(p-fluorophenyl)propan-2-one; p-Fluorophenacyl Chloride; 4-Fluorophenacyl Chloride; 2-Chloro-4'-fluoroacetophenone; α-Chloro-4'-fluoroacetophenone; 1-(4-Fluorophenyl)-2-chloroethanone
EINECS	Contact for details

Quality Control

Our 1-Chloro-1-(4-Fluorophenyl)Propan-2-One is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for prolonged operations to minimize degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.