Description

(1S,2S)-trans-1,2,3,4-Tetrahydro-1,2-Naphthalenediol is a high-purity, chiral diol derivative of tetralin, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in its defined stereochemistry, which is essential for imparting specific biological activity or material properties in the final product. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing enantiomerically pure active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where specific stereochemistry can enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for chiral polymers and advanced organic materials.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex fragrance and flavor compounds.
• Academic & R&D: A valuable reagent for methodological development in stereoselective synthesis and catalysis studies.

Basic Information

Product Name	(1S,2S)-trans-1,2,3,4-Tetrahydro-1,2-Naphthalenediol
CAS No.	23190-43-4
Molecular Formula	C10H12O2
Molecular Weight	164.20 g/mol
Synonyms	(1S,2S)-1,2,3,4-Tetrahydro-1,2-naphthalenediol; (1S,2S)-1,2-Dihydroxy-1,2,3,4-tetrahydronaphthalene; trans-(1S,2S)-1,2,3,4-Tetrahydro-1,2-naphthalenediol; (1S,2S)-THND; (1S,2S)-Tetralin-1,2-diol; (1S,2S)-1,2-Dihydroxytetralin; (1S,2S)-1,2,3,4-Tetrahydroxy-1,2-naphthalenediol (incorrect but common search variant); trans-1,2-Dihydroxy-1,2,3,4-tetrahydronaphthalene (stereoisomer unspecified)
EINECS	Contact for details

Quality Control

Our (1S,2S)-trans-1,2,3,4-Tetrahydro-1,2-Naphthalenediol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and cGMP-grade standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.