Description

4H-1-Benzopyran-4-One, 5,6,7,8-Tetrafluoro- is a high-value, fluorinated chromone derivative, a key synthetic intermediate prized for its unique electronic properties imparted by the tetrafluoro substitution. This compound is essential for researchers and manufacturers developing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is critical for modulating biological activity, stability, and lipophilicity. It is primarily utilized in the pharmaceutical, agrochemical, and specialty chemical sectors for the synthesis of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where fluorine incorporation enhances efficacy and environmental stability.
• Material Science Research: Acts as a precursor for fluorinated organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport materials.
• Fluorinated Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products for mechanism-of-action studies and bioimaging.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring precise fluorination patterns on a chromone scaffold.

Basic Information

Product Name	4H-1-Benzopyran-4-One, 5,6,7,8-Tetrafluoro-
CAS No.	22697-40-1
Molecular Formula	C9H2F4O2
Molecular Weight	218.11 g/mol
Synonyms	5,6,7,8-Tetrafluoro-4H-chromen-4-one; 5,6,7,8-Tetrafluoro-4H-1-benzopyran-4-one; Tetrafluorochromone; 4H-Chromen-4-one, 5,6,7,8-tetrafluoro-; 5,6,7,8-Tetrafluorochromone; Chromone, 5,6,7,8-tetrafluoro-; 5,6,7,8-Tetrafluoro-4-chromone
EINECS	Contact for details

Quality Control

Our 4H-1-Benzopyran-4-One, 5,6,7,8-Tetrafluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.