Description

(3S)-2,3,4,5,6,7-Hexahydro-7,7,8-Trimethyl-1H-3Aα,6α-Methanoazulene-3α-Carboxylic Acid Methyl Ester is a high-purity, stereochemically defined synthetic intermediate of significant value in advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex molecular architectures, particularly in the fragrance and pharmaceutical sectors. It is essential for research and development chemists and manufacturers requiring a reliable source of this specific enantiomer for the production of high-value specialty chemicals.

Application

• Fragrance & Flavor Synthesis: A key chiral precursor for the synthesis of sophisticated amber, woody, and musk odorants in premium perfumery.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs) that require its specific tricyclic, decalin-like core structure.
• Organic Synthesis Research: A valuable starting material in academic and industrial labs for methodological studies in stereoselective synthesis and natural product analog creation.
• Fine Chemical Production: Employed in the manufacture of other high-value specialty chemicals where its rigid, functionalized carbon skeleton is advantageous.
• Agrochemical Intermediates: Potential use in the synthesis of novel, biologically active compounds for crop protection research.

Basic Information

Product Name	(3S)-2,3,4,5,6,7-Hexahydro-7,7,8-Trimethyl-1H-3Aα,6α-Methanoazulene-3α-Carboxylic Acid Methyl Ester
CAS No.	22628-42-8
Molecular Formula	C₁₆H₂₄O₂
Molecular Weight	248.36 g/mol
Synonyms	Methyl (3S)-2,3,4,5,6,7-Hexahydro-7,7,8-trimethyl-1H-3a,6-methanoazulene-3-carboxylate; (3S)-Ambroxide Precursor; (3S)-(-)-Ambroxide Methyl Ester Intermediate; (3S)-3a,6-Methano-3aH-indene-3-carboxylic acid, 2,3,4,5,6,7-hexahydro-7,7,8-trimethyl-, methyl ester, (3S,3aR,6R,7aS)-rel-; (3S,3aR,6R,7aS)-2,3,4,5,6,7-Hexahydro-7,7,8-trimethyl-1H-3a,6-methanoazulene-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (3S)-2,3,4,5,6,7-Hexahydro-7,7,8-Trimethyl-1H-3Aα,6α-Methanoazulene-3α-Carboxylic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and GC/HPLC for chemical purity, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Specific Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.