Description

(E)-β-(4-Chlorophenyl)Acrylophenone is a high-purity, synthetic organic compound belonging to the class of chalcone derivatives, characterized by its α,β-unsaturated ketone structure. This chemical serves as a versatile and critical pharmaceutical intermediate and research building block for the synthesis of more complex molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting anti-inflammatory, anticancer, and antimicrobial pathways.
• Organic Synthesis Building Block: Used in Michael additions, cyclization reactions, and heterocyclic chemistry to construct complex molecular frameworks.
• Material Science Research: Investigated as a monomer or precursor for the development of organic semiconductors, nonlinear optical materials, and advanced polymers.
• Agrochemical Development: Serves as a starting material for synthesizing new active ingredients for crop protection products.
• Biochemical Research: Used in studies involving enzyme inhibition and as a probe for understanding biological mechanisms.
• Flavor & Fragrance Industry: Potential intermediate for the synthesis of specific aromatic compounds.

Basic Information

Product Name	(E)-β-(4-Chlorophenyl)Acrylophenone
CAS No.	22252-16-0
Molecular Formula	C15H11ClO
Molecular Weight	242.70 g/mol
Synonyms	(E)-3-(4-Chlorophenyl)-1-phenyl-2-propen-1-one; 3-(4-Chlorophenyl)-1-phenyl-2-propen-1-one; 4-Chlorochalcone; (E)-4'-Chlorochalcone; 1-Phenyl-3-(4-chlorophenyl)-2-propen-1-one; (E)-1-Phenyl-3-(4-chlorophenyl)prop-2-en-1-one; (E)-3-(4-Chlorophenyl)-1-phenylprop-2-en-1-one; p-Chlorochalcone
EINECS	Contact for details

Quality Control

Our (E)-β-(4-Chlorophenyl)Acrylophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108°C - 112°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.