Description

1-(Bromomethyl)-2-Methyl-4-Nitrobenzene is a versatile aromatic bromo-nitro compound that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and an electron-withdrawing nitro substituent, makes it an invaluable intermediate for constructing complex molecules. This high-purity intermediate is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring functionalized benzyl motifs.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides, leveraging its reactivity for creating targeted bioactive molecules.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, dyes, and photoactive compounds.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Custom Chemical Synthesis: A fundamental reagent for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	1-(Bromomethyl)-2-Methyl-4-Nitrobenzene
CAS No.	22162-14-7
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	2-Methyl-4-nitrobenzyl bromide; 4-Nitro-2-methylbenzyl bromide; (2-Methyl-4-nitrophenyl)methyl bromide; α-Bromo-2-methyl-4-nitrotoluene; 1-Bromomethyl-2-methyl-4-nitrobenzene; 2-Methyl-1-(bromomethyl)-4-nitrobenzene; NSC 404087; 4-Nitro-o-tolylmethyl bromide
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-2-Methyl-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque. Keep under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.